Stem Cell Interactive Assignment (due Mon 4/2)

Go to Stem Cell Interactive in links

Read the descriptions as you go, then:

1)Use the coaxing agents to cause different stem cells to grow

2)List 6 different types of stem cells, purpose, and uses in treatment

3)Draw and label the “tree” connecting the different types of cells

3/6-3/23

• Tuesday 3/6:  Transcription/Translation simulation done one at a time in groups.  Meanwhile, work on Enzyme Worksheet.
• Thursday 3/8:  Chapters 16+17 Test.  Finish Enzyme worksheet.
• Monday 3/12:  Turn in Enzyme Worksheet.  Introduce Enzyme Lab.  Practice 3 protocols today and determine limitations, advantages of each. 
• Wed 3/14:  Plan your design by experimenting with the variable and protocol you plan to use.  Make sure that you do everything in your power to control variables and come up with a plan that will provide a sufficient quantity of data.  Submit your completed Design by the end of the period (this WILL be used to assess for the design part of this lab).
• Friday 3/16:   Take data for Enzyme Inquiry.  Clean up.  Start processing data if you have time.  Completed lab due next Thursday 3/22.  Enzyme data analysis hand-out, due Tuesday.
• Tues 3/19:  Turn in Enzyme Data Analysis hand-out.  Hand out Enzyme data analysis hand-out, due Thursday.  Questions on Enzyme Inquiry write-up??  Introduce Beak of the Finch reading and go pick up books.  Start biotechnology. Stem Cell Interactive.
• Thursday 3/21:  Enzyme Inquiry Lab due.  Turn in Enzyme Data Analysis assignment.  In-class test corrections on 16+17 Test.  Stem Cell Website assignment due Monday 4/2.   Notes on stem cells and cloning.  Read 20.1-20.3

16+17 Test on Thursday

These are the topics you should know for the test on Thursday:

Chapter 16:
1)   Race to discover DNA structure (Pauling, Watson & Crick, Franklin & Wilkins)
2)  Basic structure of nucleotides and double helix, hydrogen bonding, base pairing
3)  Be able to describe the replication of DNA, using terminology and names of enzymes correctly
4)  Understand that replication has an editing process that corrects most mismatches
5)  Know what telomeres are and what happens to them in normal somatic cells as the cell divides
6)  Be able to describe the packing of chromatin in chromosomes, including the terms: histones, nucleosomes, "beads on a string"

Chapter 17:
7)  Be able to describe the processes of transciption and translation for eukaryotes using the vocabulary we used in class, which includes:  messenger RNA, RNA polymerase, 5' cap, poly-A tail, introns, exons, transfer RNA, promoter, initiation, elongation, termination, ribosomes (large subunit and small subunit), aminoacyl-tRNA synthetases, etc.
8)  Be able to use the genetic code in both directions:  determine amino acid sequence by reading code, write code for a particular amino acid sequence, understand the concepts of codons, anticodons, start signal, stop signals
9)  Be able to explain how point mutations and frameshift mutations can affect the production of a polypeptide and ultimately affect an organism's phenotype, know which type of mutation is most likely to affect the polypeptide, including where in the gene the mutation occurs

IB Topics Covered:
3.3, 3.4, 3.5, 4.1.4
7.1, 7.2, 7.3, 7.4

February 21-March 2 (updated on Feb 29)

• Tues 2/21:  Genetics Test.  Review nucleotide structure.  Read 16.1.
• Thurs 2/23:  Race to find the structure of DNA.  DNA replication.  Work on Replication worksheet.  Read 16.2.
• Mon 2/27:  DNA editing and chromosome structure.  Do replication simulation in groups.  Finish replication worksheet and turn in today.  Start transcription.  Read 16.3 and 17.1.
• Wed 2/29:  Quiz on replication.  Transcription and RNA modification.  Codes for amino acids.    Crack the Code worksheet.  Read 17.2 and 17.3.
• Fri 3/2:  Translation to form polypeptides.  Mutations and their effect on polypeptides.   Read 17.4 and 17.5.  Chapter 16+17 Test next Thursday March 8th.

Answers to Genetics Review (sorry for the delay!)

1.  a)  PPLlx PPLl, PPLl x ppLl, PPLl x PpLl and other options
b)  ppLl x ppLl
c)  PPLL x ppll, PPLL x PPLL, PPLL x PpLl and many other options
d)  PpLl x Ppll
f)  PpLl x PpLl

2.  a)  1/256   b)  1/16   c)  1/64    d)  1/128
3.  1/9
4.  3 purple, 5 white
5.  9 A+, 3 A-, 3 O+, 1 O-
6.  a)  because the genes were linked on the same chromosome and did not sort independently
b)  0.6 %

Computer Lab on February 13

DO THIS IN GROUPS OF 3 TO 4 STUDENTS!

1) Go to the University of Utah site on genetics library (see link to right)
2) Each student picks one Level 3, one Level 2, and one Level 1 disorder.  Each person in your group should do a different disorder.  When it comes to Level 1, each group should have a person do cystic fibrosis and sickle cell disease.
3)  Independently (20 minutes):  each person writes down type(s) of genetic transmission (recessive, dominant, x-linked, autosomal, missing chromosome, multifactorial, etc), symptoms, possible treatments, and anything else you think your group members should know.  
4)  In your group (20 minutes):  each person in the group verbally shares the important facts they have learned about their 3 disorders.  Other groups members ask questions and write down what the member has shared.  List the name of each student with the disorders they talked about.
5)  Turn in your paper to Ms. Kenny.  You will get back to on Wednesday to use for test preparation.
6)  When you finish, work on Pedigree Worksheet and then work on Genetics Review.

February 7-February 21

• Tues 2/7:  Hand Final Exams back and recollect.  2nd Semester Survey.  Rules of Probability.  Beyond regular Mendelian genetics.  Hand out Genetics Problem Set.  Due next Monday, 2/13.  Read 14.3. 
• Thurs 2/9:  Card Simulations and Chi Squared Test.  Human genetic disorders.  Sex-linked traits.  More on pedigrees.   Thacker family pedigree problem.  Pedigree Worksheet due Wednesday.   Read 14.4 and 15.2.
• Mon 2/13:  Turn in genetics problem set.  Genetic recombination and linkage.  Map units.  Alteration of chromosome number  and structure. Library Research of genetic disorders.   Read 15.3 and 15.4.
• Wed 2/15:  Turn in Pedigree Problems.  Exceptions to standard chromosome theory.  Video on epigenetics.  Read 15.5
• Fri 2/17:  Senior Seminar Day.  All classes meet for a short time.  Chapters 14+15 wrap-up.  Test on Tues 2/21.
• Mon 2/20:  President's Day.  No school.
• Tues 2/21:  Chapter 14+15 Test.  Start Chapter 16 on DNA.  Read 16.1.